1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde

Base Information

• Chemical Name: 1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde
• CAS No.: 1465885-15-7
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.236
• Mol file: 1465885-15-7.mol

Synonyms:1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde

Chemical Property of 1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Oxo-2-phenylethyl)-1H-pyrrole-2-carbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Building block is employed in the enantioselective synthesis of 5,6-dihydroindolizines through a cascade sequence initiated by (S)-(–)-α,α-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether (Aldrich 677183).

Technology Process of 1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde

There total 2 articles about 1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-pyrrole aldehyde (1003-29-8,254729-95-8) + α-bromoacetophenone (70-11-1) → 1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde (1465885-15-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1021/jo401801j

Reference yield:

acetophenone (98-86-2) → 1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde (1465885-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / diethyl ether / 12 h / 20 °C

2: potassium carbonate / acetonitrile / 12 h / 20 °C

With bromine; potassium carbonate; In diethyl ether; acetonitrile;

DOI:10.1016/j.tet.2018.08.022

Reference yield: 98.0%

1-(2-oxo-2-phenylethyl)-1H-pyrrole-2-carboxaldehyde (1465885-15-7) + ethyl acetoacetate (141-97-9) → ethyl 5-benzoyl-6-methylindolizine-7-carboxylate

Guidance literature:

With piperdinium acetate; In ethanol; at 120 ℃; for 24h; Concentration; Reagent/catalyst; Solvent; Temperature; Sealed tube;

DOI:10.1021/jo401801j

upstream raw materials:

2-pyrrole aldehyde

α-bromoacetophenone

acetophenone

Refernces

• 1、 Shao, Nana,Li, Jinbiao,Zhu, Huajian,Zhang, Shuaizhong,Zou, Hongbin. "Functionalized N-containing heterocyclic scaffolds derived from N-substituted pyrroles via inter- and intramolecular annulations". supporting information. p. 6088 - 6094. Retrieved 2018/09/17.
• 2、 -. "Indolizine derivatives, pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition containing the same as an active ingredient". Paragraph 0203-0205; 0227. . Retrieved 2021/06/01.