methyl 4-(dimethylamino)-3-iodo-benzoate

Base Information

• Chemical Name: methyl 4-(dimethylamino)-3-iodo-benzoate
• CAS No.: 99067-73-9
• Molecular Formula: C₁₀H₁₂INO₂
• Molecular Weight: 305.115
• Mol file: 99067-73-9.mol

Synonyms:methyl 4-(dimethylamino)-3-iodobenzoate

Chemical Property of methyl 4-(dimethylamino)-3-iodo-benzoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-(dimethylamino)-3-iodobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(dimethylamino)-3-iodo-benzoate

There total 5 articles about methyl 4-(dimethylamino)-3-iodo-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-amino-3-iodobenzoic acid methyl ester (19718-49-1) → methyl 4-(dimethylamino)-3-iodobenzoate (99067-73-9)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 0 - 20 ℃; for 4h;

DOI:10.1021/ml500423v

Reference yield: 44.0%

4-amino-3-iodobenzoic acid methyl ester (19718-49-1) + methyl iodide (74-88-4) → methyl 4-(dimethylamino)-3-iodobenzoate (99067-73-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/ol8021287 DOI:10.1021/jo9014003

Reference yield: 25.0%

3-amino-4-dimethylamino-benzoic acid methyl ester (54941-06-9) → methyl 4-(dimethylamino)-3-iodobenzoate (99067-73-9)

Guidance literature:

3-amino-4-dimethylamino-benzoic acid methyl ester; With hydrogenchloride; sodium nitrite; In water; at 0 - 3 ℃; for 0.166667h;

With potassium iodide; In water; at 3 - 20 ℃; for 0.5h;

upstream raw materials:

4-amino-3-iodobenzoic acid methyl ester

methyl iodide

formaldehyd

4-(methoxycarbonyl)-2-nitro-N,N-dimethylaniline

Downstream raw materials:

methyl 4-dimethylamino-3-(phenylethynyl)benzoate

methyl 4-(dimethylamino)-3-((trimethylsilyl)ethynyl)benzoate

9-(2-nitrophenyl)nona-6,8-diyn-1-ol

methyl 4-(dimethylamino)-3-(9-hydroxynona-1,3-diynyl)benzoate