methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate

Base Information

Chemical Name:methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate
CAS No.:1403381-87-2
Molecular Formula:C₃₂H₃₅NO₆
Molecular Weight:529.633
Hs Code.:

Synonyms:methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate

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Chemical Property of methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate

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Technology Process of methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate

There total 11 articles about methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1002727-88-9
2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1403381-86-1
methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-(tert-butoxy)acetate

: 1403381-87-2
methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 1403381-87-2
methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

2.1: thionyl chloride / 3 h / 85 °C

2.2: 15 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 - 50 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 20 °C / Inert atmosphere

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C

6.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

7.1: acetyl chloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

8.1: perchloric acid / 1 h / -10 - 0 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

With hydrogenchloride; dmap; thionyl chloride; perchloric acid; sodium hydride; diisobutylaluminium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; acetyl chloride; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 227805-74-5
N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethan-1-amine

: 1403381-87-2
methyl 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 3 h / 85 °C

1.2: 15 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 - 50 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 20 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

5.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

6.1: acetyl chloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

7.1: perchloric acid / 1 h / -10 - 0 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; perchloric acid; sodium hydride; diisobutylaluminium hydride; sodium carbonate; acetyl chloride; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;