(S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate

Base Information

Chemical Name:(S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate
CAS No.:22785-43-9
Molecular Formula:C13H14 N2 O4
Molecular Weight:262.265
Hs Code.:2924299090
DSSTox Substance ID:DTXSID70427381
Nikkaji Number:J1.092.290I
Wikidata:Q72472879
ChEMBL ID:CHEMBL25896
Mol file:22785-43-9.mol

Synonyms:22785-43-9;(S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate;benzyl N-[(3S)-2,6-dioxopiperidin-3-yl]carbamate;(S)-(2,6-DIOXO-PIPERIDIN-3-YL)-CARBAMIC ACID BENZYL ESTER;(S)-3-N-Cbz-amino-2,6-dioxopiperidine;(S)-3-N-CBZ-AMINO-2,6-DIOXO-PIPERIDINE;MFCD09878852;(S)-3-Cbz-amino-2,6-dioxopiperidine;(S)-benzyl 2,6-dioxopiperidin-3-ylcarbamate;CHEMBL25896;SCHEMBL3544056;DTXSID70427381;AKOS015998653;AS-18216;CS-0149747;(3S)-3beta-(Benzyloxycarbonylamino)piperidine-2,6-dione;Carbamic acid,N-[(3S)-2,6-dioxo-3-piperidinyl]-,phenylmethyl ester

Suppliers and Price of (S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-Benzyl(2,6-dioxopiperidin-3-yl)carbamate
250mg
$ 60.00

Crysdot
(S)-Benzyl(2,6-dioxopiperidin-3-yl)carbamate 97%
5g
$ 297.00

Chemenu
(S)-Benzyl(2,6-dioxopiperidin-3-yl)carbamate 97%
5g
$ 281.00

Biosynth Carbosynth
(S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate
1 g
$ 220.00

Biosynth Carbosynth
(S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate
500 mg
$ 150.00

Biosynth Carbosynth
(S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate
250 mg
$ 100.00

Biosynth Carbosynth
(S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate
5 g
$ 775.00

Biosynth Carbosynth
(S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate
2 g
$ 400.00

AstaTech
(S)-3-N-CBZ-AMINO-2,6-DIOXO-PIPERIDINE 97%
5 / G
$ 700.00

American Custom Chemicals Corporation
(S)-(2,6-DIOXO-PIPERIDIN-3-YL)-CARBAMIC ACID BENZYL ESTER 95.00%
1G
$ 697.34

Total 21 raw suppliers

Chemical Property of (S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate

Chemical Property:

Vapor Pressure:6.37E-11mmHg at 25°C
Refractive Index:1.58
Boiling Point:520.2°Cat760mmHg
Flash Point:268.4°C
PSA：91.48000
Density:1.31g/cm³
LogP:1.19830
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:262.09535693
Heavy Atom Count:19
Complexity:364

Purity/Quality:

97% ^*data from raw suppliers

(S)-Benzyl(2,6-dioxopiperidin-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC(=O)C1NC(=O)OCC2=CC=CC=C2
Isomeric SMILES:C1CC(=O)NC(=O)[C@H]1NC(=O)OCC2=CC=CC=C2
Uses (S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate is used in preparation of Lenalidomide and intermediate for its synthesis.

Technology Process of (S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate

There total 6 articles about (S)-Benzyl (2,6-dioxopiperidin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2650-64-8
Cbz-L-Gln

: 22785-43-9,179915-11-8
(S)-benzyl (2,6-dioxopiperidin-3-yl)carbamate

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 18h; Time; Temperature; Reagent/catalyst; Reflux;

Reference yield: 81.0%

: 1155-62-0
N-benzyloxycarbonyl-L-glutamic acid

: 22785-43-9,179915-11-8
(S)-benzyl (2,6-dioxopiperidin-3-yl)carbamate

Guidance literature:: With 2,2,2-trifluoroacetamide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(99)00590-0

Reference yield: 42.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 2650-64-8
Cbz-L-Gln

: 34078-85-8
N^α-carbobenzoxy-L-glutamine α-N-succinimidyl ester

: 22785-43-9,179915-11-8
(S)-benzyl (2,6-dioxopiperidin-3-yl)carbamate

Guidance literature:: With N-ethylmorpholine;; hexamethylphosphorous triamide dichloride; In dichloromethane; Title compound not separated from byproducts; 1) 0 deg C, 2 h, 2) overnight, r.t.;