Technology Process of ethyl (E)-2-methyl-3-(pyridin-2-yl)propenoate
There total 1 articles about ethyl (E)-2-methyl-3-(pyridin-2-yl)propenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
morpholine;
In
toluene;
for 4h;
Overall yield = 84 percent; Overall yield = 80 mg; stereoselective reaction;
Reflux;
Green chemistry;
DOI:10.1021/acs.orglett.9b02291
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide; water / tetrahydrofuran / 25 °C
2.1: thionyl chloride / 95 °C
3.1: triethylamine / tetrahydrofuran / 0 - 25 °C
4.1: trifluoroacetic acid / dichloromethane / 0 °C
5.1: thionyl chloride / 95 °C
5.2: 25 °C
6.1: triethylamine / N,N-dimethyl-formamide / 25 °C
With
thionyl chloride; water; triethylamine; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/d1sc04019g
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium hydroxide; water / tetrahydrofuran / 25 °C
2.1: thionyl chloride / 95 °C
3.1: triethylamine / tetrahydrofuran / 0 - 25 °C
4.1: trifluoroacetic acid / dichloromethane / 0 °C
5.1: thionyl chloride / 95 °C
5.2: 25 °C
6.1: triethylamine / N,N-dimethyl-formamide / 25 °C
7.1: potassium hydroxide / N,N-dimethyl-formamide / 25 °C
With
thionyl chloride; water; triethylamine; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/d1sc04019g
