C₃₂H₂₈F₂N₂O₃

Base Information

• Chemical Name: C₃₂H₂₈F₂N₂O₃
• CAS No.: 1210859-32-7
• Molecular Formula: C₃₂H₂₈F₂N₂O₃
• Molecular Weight: 526.583
• Mol file: 1210859-32-7.mol

Synonyms:C₃₂H₂₈F₂N₂O₃

Chemical Property of C₃₂H₂₈F₂N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₃₂H₂₈F₂N₂O₃

There total 1 articles about C₃₂H₂₈F₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone (1210859-23-6) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → 4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid (1210856-74-8) + C32H28F2N2O3 (1210859-32-7) + C33H30F2N2O3 (1210859-34-9)

Guidance literature:

ethanol; 2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone; 4-methoxycarbonylphenylboronic acid; With water; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; at 130 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In ethanol; water; ethyl acetate;

Reference yield:

C32H28F2N2O3 (1210859-32-7) + C33H30F2N2O3 (1210859-34-9) → 4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid (1210856-74-8)

Guidance literature:

C₃₂H₂₈F₂N₂O₃; C₃₃H₃₀F₂N₂O₃; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 2.5h;

With hydrogenchloride; In methanol; water; ethyl acetate; pH=2;

upstream raw materials:

ethanol

2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone

4-methoxycarbonylphenylboronic acid

Downstream raw materials:

4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid