methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate

Base Information

Chemical Name:methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate
CAS No.:223406-02-8
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate

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Chemical Property of methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate

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Technology Process of methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate

There total 4 articles about methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68641-16-7
(4-benzyloxy-phenyl)-acetic acid methyl ester

: 223406-02-8
methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 2 h / -20 °C

2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 2 h / -20 °C

3.1: ozone / CH₂Cl₂ / -78 °C

3.2: 44.6 g / triphenylphosphine / CH₂Cl₂ / 1 h / 20 °C

4.1: Zn; HOAc / Heating

With sodium hexamethyldisilazane; ozone; acetic acid; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0255670

Reference yield:

: 89618-33-7
methyl 2-(4-benzyloxyphenyl)propionate

: 223406-02-8
methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran / 2 h / -20 °C

2.1: ozone / CH₂Cl₂ / -78 °C

2.2: 44.6 g / triphenylphosphine / CH₂Cl₂ / 1 h / 20 °C

3.1: Zn; HOAc / Heating

With sodium hexamethyldisilazane; ozone; acetic acid; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0255670

Reference yield:

: 223405-99-0
2-(4-benzyloxy-phenyl)-2-methyl-pent-4-enoic acid methyl ester

: 223406-02-8
methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / CH₂Cl₂ / -78 °C

1.2: 44.6 g / triphenylphosphine / CH₂Cl₂ / 1 h / 20 °C

2.1: Zn; HOAc / Heating

With ozone; acetic acid; zinc; In dichloromethane;
DOI:10.1021/jm0255670