7-Chloro-2H-1,4-benzoxazin

Base Information

• Chemical Name: 7-Chloro-2H-1,4-benzoxazin
• CAS No.: 27320-99-6
• Molecular Formula: C8H6ClNO2
• Molecular Weight: 183.59
• Hs Code.: 2934999090
• Mol file: 27320-99-6.mol

Synonyms:7-Chloro-4H-benzo[1,4]oxazin-3-one;7-Chloro-2H-1,4-benzoxazin-3(4H)-one;7-Chloro-2H-benzo[b][1,4]oxazin-3(4H)-one;

Chemical Property of 7-Chloro-2H-1,4-benzoxazin

Chemical Property:

• Vapor Pressure: 0.00115mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 367.766 °C at 760 mmHg
• Flash Point: 176.219 °C
• PSA: 38.33000
• Density: 1.393 g/cm³
• LogP: 1.80890
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

7-Chloro-2h-1,4-benzoxazin-3(4h)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Chloro-2H-1,4-benzoxazin

There total 15 articles about 7-Chloro-2H-1,4-benzoxazin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-amino-5-chlorophenol (28443-50-7) + 2-Bromoacetyl bromide (598-21-0) → 3,4-dihydro-7-chloro-3-oxo-2H-1,4-benzoxazine (27320-99-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

DOI:10.1002/cmdc.201500301

Reference yield: 50.0%

2,4-dichlorophenol (120-83-2,40477-79-0) + Chloroacetamide (79-07-2) → 3,4-dihydro-7-chloro-3-oxo-2H-1,4-benzoxazine (27320-99-6)

Guidance literature:

With caesium carbonate; at 130 ℃; Microwave irradiation;

DOI:10.5012/jkcs.2012.56.4.468

Reference yield: 22.0%

4-hydroxy-2H-1,4-benzoxazin-3-one (771-26-6) → 3,4-dihydro-7-chloro-3-oxo-2H-1,4-benzoxazine (27320-99-6)

Guidance literature:

With hydrogenchloride; for 2.5h; Heating;

DOI:10.1248/cpb.31.3891

upstream raw materials:

3,4-dihydro-3-oxo-2H-1,4-benzoxazine

2-nitrophenoxyacetic acid

ethyl o-nitrophenoxyacetate

4-hydroxy-2H-1,4-benzoxazin-3-one

Downstream raw materials:

C₂₀H₁₈Cl₂N₄O₂S

Refernces

• 1、 Spinks, Daniel,Smith, Victoria,Thompson, Stephen,Robinson, David A.,Luksch, Torsten,Smith, Alasdair,Torrie, Leah S.,McElroy, Stuart,Stojanovski, Laste,Norval, Suzanne,Collie, Iain T.,Hallyburton, Irene,Rao, Bhavya,Brand, Stephen,Brenk, Ruth,Frearson, Julie A.,Read, Kevin D.,Wyatt, Paul G.,Gilbert, Ian H.. "Development of small-molecule Trypanosoma brucei N-myristoyltransferase inhibitors: Discovery and optimisation of a novel binding mode". . p. 1821 - 1836. Retrieved 2015/11/10.
• 2、 -. "MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE". Page/Page column 76. . Retrieved 2010/11/26.