4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide
CAS No.:1362818-47-0
Molecular Formula:C₂₄H₂₃F₃N₄O₃
Molecular Weight:472.467
Hs Code.:

Synonyms:4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide

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Chemical Property of 4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of 4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide

There total 11 articles about 4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20744-39-2
4-aminopyridazine

: 1362820-69-6
4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoic acid

: 1362818-47-0
4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3h;

Reference yield:

: 81245-24-1
methyl 4-methyl-2-methoxybenzoate

: 1362818-47-0
4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: bromine / chloroform / 1.08 h / 0 °C

2: copper(l) iodide / N,N-dimethyl-formamide; toluene / 18.75 h / 170 °C

3: boron tribromide / dichloromethane / 2 h / 0 °C

4: pyridine / 2 h

5: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

6: triethylamine / acetone / 2 h

7: caesium carbonate / N,N-dimethyl-formamide / 18 h / 40 °C

8: water; lithium hydroxide / tetrahydrofuran / 2 h / 40 °C

9: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h

With pyridine; N-Bromosuccinimide; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; water; bromine; boron tribromide; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1362818-47-0
4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-4-pyridazinyl-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / acetone / 5 h / 50 °C

2: bromine / chloroform / 1.08 h / 0 °C

3: copper(l) iodide / N,N-dimethyl-formamide; toluene / 18.75 h / 170 °C

4: boron tribromide / dichloromethane / 2 h / 0 °C

5: pyridine / 2 h

6: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

7: triethylamine / acetone / 2 h

8: caesium carbonate / N,N-dimethyl-formamide / 18 h / 40 °C

9: water; lithium hydroxide / tetrahydrofuran / 2 h / 40 °C

10: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h

With pyridine; N-Bromosuccinimide; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; water; bromine; boron tribromide; potassium carbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; toluene;