4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione

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Chemical Name:4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione
CAS No.:1443021-93-9
Molecular Formula:C₃₂H₂₃Cl₂FN₂O₂
Molecular Weight:557.451
Hs Code.:

Synonyms:4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione

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Chemical Property of 4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione

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Technology Process of 4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione

There total 5 articles about 4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1-(4-chlorophenyl)-3-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)prop-2-en-1-one

: 459-57-4
4-fluorobenzaldehyde

: 1443021-93-9
4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione

Guidance literature:: With potassium cyanide; In N,N-dimethyl-formamide; at 30 - 35 ℃; for 4h;
DOI:10.1016/j.ejmech.2013.03.005

Reference yield:

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1443021-93-9
4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / ethanol / 24 h / 20 °C

2: trichlorophosphate / 5 h / 0 - 80 °C

3: sodium hydroxide / ethanol; water / 24 h / 20 °C

4: potassium cyanide / N,N-dimethyl-formamide / 4 h / 30 - 35 °C

With potassium cyanide; acetic acid; sodium hydroxide; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; 3: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2013.03.005

Reference yield:

: 386272-18-0
1-(4-chlorophenyl)-2-(1-p-tolylethylidene)hydrazine

: 1443021-93-9
4-(4-chlorophenyl)-2-(1-(4-chlorophenyl)-3-p-tolyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)butane-1,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 5 h / 0 - 80 °C

2: sodium hydroxide / ethanol; water / 24 h / 20 °C

3: potassium cyanide / N,N-dimethyl-formamide / 4 h / 30 - 35 °C

With potassium cyanide; sodium hydroxide; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; 2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2013.03.005