N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one

Base Information

• Chemical Name: N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one
• CAS No.: 936097-24-4
• Molecular Formula: C₂₂H₂₄ClNO₄
• Molecular Weight: 401.89
• Mol file: 936097-24-4.mol

Synonyms:N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one

Chemical Property of N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one

There total 2 articles about N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,6-di(p-methoxyphenyl)-3-methylpiperidin-4-one (115584-11-7,138453-07-3) + chloroacetyl chloride (79-04-9) → N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one (936097-24-4)

Guidance literature:

With triethylamine; In benzene; at 30 - 35 ℃;

DOI:10.1080/00397910601163828

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one (936097-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OAc / ethanol / Heating

2: 83 percent / triethylamine / benzene / 30 - 35 °C

With ammonium acetate; triethylamine; In ethanol; benzene; 1: Mannich reaction;

DOI:10.1016/j.ejmech.2006.12.005

Reference yield: 82.0%

1-methyl-piperazine (109-01-3) + N-chloroacetyl-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one (936097-24-4) → N-[(4-methylpiperazino)acetyl]-3-methyl-2,6-bis(p-methoxyphenyl)piperidin-4-one

Guidance literature:

With triethylamine; In toluene; for 8h; Reflux;

DOI:10.1016/j.ejmech.2008.03.031

upstream raw materials:

2,6-di(p-methoxyphenyl)-3-methylpiperidin-4-one

chloroacetyl chloride

4-methoxy-benzaldehyde

Downstream raw materials:

1-[2-(1H-benzimidazol-1-yl)acetyl]-3-methyl-2,6-bis(4-methoxyphenyl)piperidin-4-one