2-Chloro-4-methoxy-6-methylpyrimidine

Base Information

• Chemical Name: 2-Chloro-4-methoxy-6-methylpyrimidine
• CAS No.: 22536-64-7
• Molecular Formula: C6H7 Cl N2 O
• Molecular Weight: 158.587
• Hs Code.: 2933599090
• Mol file: 22536-64-7.mol

Synonyms:2-Chloro-4-methoxy-6-methylpyrimidine;2-Chloro-4-methyl-6-methoxypyrimidine

Chemical Property of 2-Chloro-4-methoxy-6-methylpyrimidine

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Melting Point: 22-25℃
• Refractive Index: 1.518
• Boiling Point: 268.4°Cat760mmHg
• Flash Point: 116.1°C
• PSA: 35.01000
• Density: 1.237g/cm³
• LogP: 1.44700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-4-methoxy-6-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-methoxy-6-methylpyrimidine

There total 3 articles about 2-Chloro-4-methoxy-6-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

2,4-dichloro-6-methylpyrimidine (5424-21-5) + sodium methylate (124-41-4) → 2-chloro-4-methoxy-6-methyl-pyrimidine (22536-64-7)

Guidance literature:

With methanol; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 8.0%

2-amino-6-methoxy-4-methylpyrimidine (7749-47-5) → 2-chloro-4-methoxy-6-methyl-pyrimidine (22536-64-7)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 - 20 ℃; for 1.5h;

Reference yield:

→ 2-chloro-4-methoxy-6-methyl-pyrimidine (22536-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol

2: aqueous NaNO₂; aqueous HCl

With hydrogenchloride; methanol; sodium nitrite;

upstream raw materials:

2,4-dichloro-6-methylpyrimidine

sodium methylate

2-amino-6-methoxy-4-methylpyrimidine

Downstream raw materials:

2-Hydrazino-4-methoxy-6-methyl-pyrimidin

2-(4-methoxy-6-methyl-pyrimidin-2-yl)-7-[1-(toluene-4-sulfonyl)-1H-indol-3-ylmethyl]-2,7-diaza-spiro[4.5]decan-6-one

2-diethylamino-4-hydroxy-6-methyl-pyrimidine

4-chloro-2-N,N-di-n-butylamino-6-methylpyrimidine

Refernces

• 1、 -. "SUBSTITUTED 2, 4-DIAMINO-QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES". Page/Page column 176; 177. . Retrieved 2017/12/13.