(R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Base Information

• Chemical Name: (R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal
• CAS No.: 1255928-89-2
• Molecular Formula: C₁₅H₁₇NO₃
• Molecular Weight: 259.305
• Mol file: 1255928-89-2.mol

Synonyms:(R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Chemical Property of (R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

There total 2 articles about (R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) + isobutyraldehyde (78-84-2) → (R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1255928-89-2)

Guidance literature:

With 1-((1R,2R)-2-aminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea; In dichloromethane; at 20 ℃; for 6h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tet.2010.09.044

Reference yield:

1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) + isobutyraldehyde (78-84-2) → (S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal (1242461-33-1) + (R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1255928-89-2)

Guidance literature:

With C₁₃H₂₈N₄; In water; N,N-dimethyl-formamide; at 25 ℃; Overall yield = 99 %; enantioselective reaction;

DOI:10.1016/j.tetasy.2012.11.002

upstream raw materials:

1-benzyl-1H-pyrrole-2,5-dione

isobutyraldehyde