(S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal

Base Information

• Chemical Name: (S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal
• CAS No.: 1242461-33-1
• Molecular Formula: C₁₅H₁₇NO₃
• Molecular Weight: 259.305
• Mol file: 1242461-33-1.mol

Synonyms:(S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal

Chemical Property of (S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal

There total 2 articles about (S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) + isobutyraldehyde (78-84-2) → (S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal (1242461-33-1)

Guidance literature:

With C₆₄H₉₄N₆O₄S₂; In dichloromethane; at 20 ℃; enantioselective reaction;

DOI:10.1016/j.tetasy.2013.09.010

Reference yield:

1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) + isobutyraldehyde (78-84-2) → (S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal (1242461-33-1) + (R)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1255928-89-2)

Guidance literature:

With C₁₃H₂₈N₄; In water; N,N-dimethyl-formamide; at 25 ℃; Overall yield = 99 %; enantioselective reaction;

DOI:10.1016/j.tetasy.2012.11.002

Reference yield:

di-isopropyl azodicarboxylate (2446-83-5) + (S)-2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methyl propanal (1242461-33-1) → (S)-diisopropyl 1-(2-(1-benzyl-2,5-dioxopyrrolidin-3-yl)-2-methylpropanoyl)hydrazine-1,2-dicarboxylate

Guidance literature:

With benzoin monomethyl ether; In water; for 24h; UV-irradiation;

DOI:10.1039/c8nj04274h

upstream raw materials:

1-benzyl-1H-pyrrole-2,5-dione

isobutyraldehyde