N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide

Base Information

Chemical Name:N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide
CAS No.:1233249-31-4
Molecular Formula:C₂₇H₂₄ClN₃O₃
Molecular Weight:473.959
Hs Code.:

Synonyms:N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide

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Chemical Property of N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide

Chemical Property:

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Technology Process of N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide

There total 9 articles about N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233250-13-9
N-[2-(4-chlorophenyl)ethyl]-4-[(4-{2-oxo-2-[(tetrahydro-2H-pyran-2-yloxy)amino]ethyl}isoquinolin-1-yl)methyl]benzamide

: 1233249-31-4
N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide

Guidance literature:: With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

: 1233248-29-7
2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

: 1233249-31-4
N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 1 h / 20 °C

2: hydrogenchloride / ethyl acetate; methanol / 3 h / 20 °C / Cooling with ice

With hydrogenchloride; 1-hydroxy-1H-benzotriazol hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1233249-89-2
tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

: 1233249-31-4
N-[2-(4-chlorophenyl)ethyl]-4-({4-[2-(hydroxyamino)-2-oxoethyl]isoquinolin-1-yl}methyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -30 - 50 °C

1.2: 2 h / 60 °C

1.3: pH 5

2.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 50 °C

2.2: pH 5

3.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1.17 h / Cooling with ice

3.2: 3 h / Cooling with ice

4.1: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

4.2: pH 5 / Cooling with ice

5.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / Cooling with ice

5.2: 1 h / Cooling with ice

6.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 20 °C / Cooling with ice

6.2: pH 5

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 1 h / 20 °C

8.1: hydrogenchloride / ethyl acetate; methanol / 3 h / 20 °C / Cooling with ice

With hydrogenchloride; oxalyl dichloride; 1-hydroxy-1H-benzotriazol hydrate; water; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;