N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester

Base Information

Chemical Name:N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester
CAS No.:120363-15-7
Molecular Formula:C₃₂H₂₉NO₈
Molecular Weight:555.584
Hs Code.:

Synonyms:N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester

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Chemical Property of N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester

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Technology Process of N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester

There total 9 articles about N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 120363-14-6
4-[2-Benzyloxy-5-((S)-2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzoic acid tert-butyl ester

: 120363-15-7
4-[2-Benzyloxy-5-((S)-2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzoic acid

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 25 ℃; for 1.5h;
DOI:10.1021/jo00272a003

Reference yield: 51.0%

: 1005-30-7
sodium 4-iodo-benzoate

: 105229-41-2
N-[(phenylmethoxy)carbonyl]-3-hydroxy-O-(phenylmethyl)-L-tyrosine methyl ester

: 120363-15-7
4-[2-Benzyloxy-5-((S)-2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzoic acid

Guidance literature:: With copper(I) bromide dimethylsulfide complex; In nitrobenzene; at 130 ℃; for 8h;
DOI:10.1016/S0040-4039(01)93447-1

Reference yield:

: 120363-13-5
tert-butyl 4-iodobenzoate

: 120363-15-7
N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH, CuBrSMe₂ / nitrobenzene / 8 h / 130 °C

2: 95 percent / 3M HCl / ethyl acetate / 1.5 h / 25 °C

With hydrogenchloride; copper(I) bromide dimethylsulfide complex; sodium hydride; In ethyl acetate; nitrobenzene;
DOI:10.1016/S0040-4039(01)93709-8