N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester

Base Information

• Chemical Name: N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester
• CAS No.: 120385-11-7
• Molecular Formula: C₃₂H₃₁NO₇
• Molecular Weight: 541.601

Synonyms:N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester

Chemical Property of N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester

Chemical Property:

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Technology Process of N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester

There total 13 articles about N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-[2-Benzyloxy-5-((S)-2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzoic acid (120363-15-7) → N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester (120385-11-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1016/S0040-4039(01)93447-1 DOI:10.1021/jo00272a003

Reference yield: 89.0%

N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester (120363-15-7) → 2-Benzyloxycarbonylamino-3-[4-benzyloxy-3-(4-hydroxymethyl-phenoxy)-phenyl]-propionic acid methyl ester (120385-11-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1016/S0040-4039(01)93709-8

Reference yield: 89.0%

N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester (120363-15-7) → N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine methyl ester (120385-11-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; 1) 1 h, 0 deg C 2) to 25 deg C, 2 h;

DOI:10.1021/jo00311a019

upstream raw materials:

N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-(4-carboxyphenoxy)-L-tyrosine methyl ester

4-[2-Benzyloxy-5-((S)-2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-phenoxy]-benzoic acid

sodium 4-iodo-benzoate

tert-butyl 4-iodobenzoate

Downstream raw materials:

N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(hydroxymethyl)phenoxy>-L-tyrosine

N-<(Phenylmethoxy)carbonyl>-O-(phenylmethyl)-3-<4-(bromomethyl)phenoxy>-L-tyrosine methyl ester

OF4949-IV

OF4949-III

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