p-Methoxymethamphetamine

Base Information

• Chemical Name: p-Methoxymethamphetamine
• CAS No.: 22331-70-0
• Deprecated CAS: 88543-18-4
• Molecular Formula: C11H17 N O
• Molecular Weight: 179.262
• Hs Code.: 2922299090
• European Community (EC) Number: 244-917-6
• UNII: 037U5SR9KL
• DSSTox Substance ID: DTXSID30874251
• Nikkaji Number: J50.049F
• Wikipedia: Para-Methoxy-N-methylamphetamine
• Wikidata: Q1948506
• ChEMBL ID: CHEMBL1405074
• Mol file: 22331-70-0.mol

Synonyms:(+-)-isomer of 4-methoxymethamphetamine;4-methoxymethamphetamine;4-methoxymethamphetamine hydrochloride;4-PMMA;HCl of 4-methoxymethamphetamine;HCl(+-)-isomer of 4-methoxymethamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of p-Methoxymethamphetamine

Chemical Property:

• Melting Point: 175-176 °C
• Boiling Point: 262.9°Cat760mmHg
• PKA: 10.53±0.10(Predicted)
• Flash Point: 106.6°C
• PSA: 21.26000
• Density: 0.951g/cm³
• LogP: 2.23650
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 179.131014166
• Heavy Atom Count: 13
• Complexity: 130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)OC)NC
• Uses: p-methoxy-N,alpha-dimethylphenethylamine is an antinociception. Evokes stereotypic behavior related to dopaminergic activation. Illegal psychedelic drug, that can cause intoxication and fatalities in ingested.

Technology Process of p-Methoxymethamphetamine

There total 12 articles about p-Methoxymethamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-[2-(4-methoxyphenyl)-1-methyl-ethyl]formamide (126002-14-0) → p-Methoxymethamphetamine (22331-70-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Heating;

Reference yield: 80.0%

1-methoxy-4-(prop-1-yn-1-yl)benzene (2749-94-2) + methylamine (74-89-5) → N-methyl-N-[1-(4-methoxyphenyl)propyl]amine (40023-80-1) + p-Methoxymethamphetamine (22331-70-0)

Guidance literature:

1-methoxy-4-(prop-1-yn-1-yl)benzene; methylamine; Ind₂TiMe₂; In toluene; at 105 ℃; for 7h; under 760 Torr;

With sodium cyanoborohydride; zinc(II) chloride; In methanol; toluene; at 25 ℃; for 16h;

DOI:10.1002/ejoc.200500458

Reference yield: 55.0%

2-{[2-(4-Methoxy-phenyl)-1-methyl-ethyl]-methyl-amino}-2-phenyl-ethanol → p-Methoxymethamphetamine (22331-70-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

upstream raw materials:

formaldehyd

2-amino-1-(4-methyoxyphenyl)propane

4-methoxybenzyl methyl ketone

methylamine

Downstream raw materials:

C₁₃H₁₆F₃NO₂

N,N-dimethyl-1-(4-hydroxyphenyl)-2-propylamine

N-<1-(4-Methoxyphenyl)prop-2-yl>-N-methylcarbamidsaeureethylester

Formyl(N,α-dimethyl-p-methoxy)phenylethylamin

Refernces

• 1、 Fotsch,Sonnenberg,Chen,Hale,Karbon,Norman. "Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists". . p. 2344 - 2356. Retrieved 2007/10/03.
• 2、 Marco, Jose L.,Royer, Jacques,Husson, Henri-Philippe. "ASYMMETRIC SYNTHESIS IX: PREPARATION OF CHIRAL α-SUBSTITUTED PHENETHYLAMINES". . p. 669 - 676. Retrieved 2007/10/02.