6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine

Base Information

• Chemical Name: 6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine
• CAS No.: 56173-05-8
• Molecular Formula: C₁₀H₇F₃N₆
• Molecular Weight: 268.201
• Mol file: 56173-05-8.mol

Synonyms:6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine

Chemical Property of 6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine

There total 1 articles about 6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine (56173-05-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrazine hydrate; acetic acid / 120 °C

2: trichlorophosphate / 110 °C

3: hydrazine hydrate / ethanol / 78 °C

4: 140 °C

5: hydrazine hydrate; potassium carbonate / ethanol / 120 °C

With potassium carbonate; hydrazine hydrate; acetic acid; trichlorophosphate; In ethanol;

DOI:10.1016/j.bioorg.2020.103899

Reference yield: 80.0%

6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine (56173-05-8) + benzaldehyde (100-52-7) → 6-(2-benzylidenehydrazinyl)-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine

Guidance literature:

With acetic acid; In ethanol; at 120 ℃; for 4h;

DOI:10.1016/j.bioorg.2020.103899

Reference yield: 79.0%

6-hydrazinyl-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine (56173-05-8) + 4-methoxy-benzaldehyde (123-11-5) → 6-(2-(4-methoxybenzylidene)hydrazinyl)-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazine

Guidance literature:

With acetic acid; In ethanol; at 120 ℃; for 4h;

DOI:10.1016/j.bioorg.2020.103899

upstream raw materials:

phthalic anhydride