ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

Base Information

Chemical Name:ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate
CAS No.:1010839-84-5
Molecular Formula:C₁₇H₂₀F₂O₆
Molecular Weight:358.339
Hs Code.:

Synonyms:ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

Suppliers and Price of ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

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Technology Process of ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

There total 2 articles about ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 98-88-4
benzoyl chloride

: 928797-50-6,166376-97-2
ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate

: 1010839-84-5
ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

Guidance literature:: With 2,6-dimethylpyridine; dmap; In dichloromethane; at 33 - 36 ℃; for 3h;
DOI:10.1055/s-1992-26167

Reference yield:

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 1010839-84-5
ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: Zn / diethyl ether; tetrahydrofuran

2: 96 percent / 2,6-lutidine / 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 33 - 36 °C

With 2,6-dimethylpyridine; zinc; dmap; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1055/s-1992-26167