(D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate

Base Information

Chemical Name:(D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate
CAS No.:1217526-42-5
Molecular Formula:C₁₉H₁₄F₂O₆
Molecular Weight:376.313
Hs Code.:

Synonyms:(D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate

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Technology Process of (D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate

There total 4 articles about (D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 98-88-4
benzoyl chloride

: 122111-07-3,122111-08-4
(D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3-benzoate

: 1217526-42-5,122111-02-8
(D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate

Guidance literature:: With pyridine; dmap; In ethyl acetate; at 65 ℃; for 2h;
DOI:10.1055/s-1992-26167

Reference yield:

: 98-88-4
benzoyl chloride

: 1217526-42-5,122111-02-8
(D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 2,6-lutidine / 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 33 - 36 °C

2: 1) trifluoroacetic acid, water, 2) toluene / 1) CH₃CN, 78 deg C, 3 h, 2) azeotropic distillation until 95-100 deg C (pot temperature)

3: 100 percent / pyridine, 4-dimethylaminopyridine / ethyl acetate / 2 h / 65 °C

With pyridine; 2,6-dimethylpyridine; dmap; water; toluene; trifluoroacetic acid; dmap; In dichloromethane; ethyl acetate;
DOI:10.1055/s-1992-26167

Reference yield:

: 928797-50-6,166376-97-2
ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate

: 1217526-42-5,122111-02-8
(D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3,5-dibenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 2,6-lutidine / 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 33 - 36 °C

2: 1) trifluoroacetic acid, water, 2) toluene / 1) CH₃CN, 78 deg C, 3 h, 2) azeotropic distillation until 95-100 deg C (pot temperature)

3: 100 percent / pyridine, 4-dimethylaminopyridine / ethyl acetate / 2 h / 65 °C

With pyridine; 2,6-dimethylpyridine; dmap; water; toluene; trifluoroacetic acid; dmap; In dichloromethane; ethyl acetate;
DOI:10.1055/s-1992-26167