2,4-Dimethyl-6-phenylpyridine

Base Information

• Chemical Name: 2,4-Dimethyl-6-phenylpyridine
• CAS No.: 27068-65-1
• Molecular Formula: C13H13 N
• Molecular Weight: 183.253
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60345262
• Nikkaji Number: J1.014.863D
• Wikidata: Q82117619
• Mol file: 27068-65-1.mol

Synonyms:2,4-Dimethyl-6-phenylpyridine;27068-65-1;SCHEMBL3848271;DTXSID60345262;AKOS006308361;FT-0706194

Chemical Property of 2,4-Dimethyl-6-phenylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 3.36540
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 183.104799419
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

2,4-DIMETHYL-6-PHENYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=C1)C2=CC=CC=C2)C

Technology Process of 2,4-Dimethyl-6-phenylpyridine

There total 29 articles about 2,4-Dimethyl-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-4,6-dimethyl pyridine (4926-26-5) + phenylboronic acid (98-80-6) → 4,6-dimethyl-2-phenyl pyridine (27068-65-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; Heating;

DOI:10.1021/jm950584t

Reference yield: 61.0%

methanol (67-56-1) + 2-phenylpyridine (1008-89-5) → 6-methyl-2-phenylpyridine (46181-30-0) + 4,6-dimethyl-2-phenyl pyridine (27068-65-1) + 4-methyl-2-phenylpyridine (3475-21-6)

Guidance literature:

With Ethyl 2-mercaptopropionate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; toluene-4-sulfonic acid; In dimethyl sulfoxide; at 23 ℃; UV-irradiation;

DOI:10.1038/nature14885

Reference yield: 45.0%

methanol (67-56-1) + 2-phenylpyridine (1008-89-5) → 4,6-dimethyl-2-phenyl pyridine (27068-65-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 12h; UV-irradiation; Sealed tube;

DOI:10.1016/j.chempr.2017.03.009

upstream raw materials:

1,3-Dimethyl-1,3-butadien

benzonitrile

acetone

(E)-benzalacetone

Downstream raw materials:

6-phenyl-2,4-pyridinecarboxylic acid

(6-phenylpyridine-2,4-diyl)dimethanol