(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate

Base Information

Chemical Name:(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate
CAS No.:1372526-44-7
Molecular Formula:C₃₅H₄₃ClN₂O₄
Molecular Weight:591.19
Hs Code.:

Synonyms:(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate

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Chemical Property of (R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate

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Technology Process of (R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate

There total 12 articles about (R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1118-02-1
trimethylsilyl isocyanate

: 1372526-26-5
(R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone

: 1372526-44-7
(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm201608g

Reference yield:

: 1372526-66-3
(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

: 1372526-44-7
(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / acetonitrile / 2 h / 20 °C

2: dmap / dichloromethane / 4 h / 20 °C

With dmap; sodium hydroxide; In dichloromethane; acetonitrile;
DOI:10.1021/jm201608g

Reference yield:

: 62810-39-3
(4-chlorophenyl)(3-hydroxyphenyl)methanone

: 1372526-44-7
(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 8 h / 20 °C

4: sodium hydroxide / acetonitrile / 2 h / 20 °C

5: dmap / dichloromethane / 4 h / 20 °C

With dmap; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jm201608g