(R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone

Base Information

Chemical Name:(R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone
CAS No.:1372526-26-5
Molecular Formula:C₃₄H₄₂ClNO₃
Molecular Weight:548.165
Hs Code.:

Synonyms:(R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone

Chemical Property:

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Technology Process of (R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone

There total 11 articles about (R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1372526-66-3
(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

: 1372526-26-5
(R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone

Guidance literature:: With sodium hydroxide; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/jm201608g

Reference yield:

: 62810-39-3
(4-chlorophenyl)(3-hydroxyphenyl)methanone

: 1372526-26-5
(R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 8 h / 20 °C

4: sodium hydroxide / acetonitrile / 2 h / 20 °C

With di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jm201608g

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 1372526-26-5
(R)-(4-chlorophenyl)(3-((1-(3-(1-hydroxyoctyl)benzyl)piperidin-4-yl)methoxy)phenyl) methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 °C

2.2: 3.5 h / -78 - 0 °C

3.1: hydrogen bromide; acetic acid / water / 36 h / 125 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 8 h / 20 °C

7.1: sodium hydroxide / acetonitrile / 2 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen bromide; isopropylmagnesium chloride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile; 4.1: Mitsunobu reaction;
DOI:10.1021/jm201608g