(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

Base Information

Chemical Name:(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate
CAS No.:1372526-66-3
Molecular Formula:C₃₆H₄₄ClNO₄
Molecular Weight:590.203
Hs Code.:

Synonyms:(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

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Chemical Property of (R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

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Technology Process of (R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

There total 11 articles about (R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1372526-65-2
(R)-1-(3-formylphenyl)octyl acetate

: 1372526-58-3
(4-chlorophenyl)(3-(piperidin-4-ylmethoxy)phenyl)methanone

: 1372526-66-3
(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1021/jm201608g

Reference yield:

: 1372526-59-4
1-(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)octan-1-one

: 1372526-66-3
(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / -78 - -15 °C

2.1: pyridine / 5 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

4.2: 1 h / -78 - 20 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 8 h / 20 °C

With pyridine; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; 4.1: Swern oxidation / 4.2: Swern oxidation;
DOI:10.1021/jm201608g

Reference yield:

: 62810-39-3
(4-chlorophenyl)(3-hydroxyphenyl)methanone

: 1372526-66-3
(R)-1-(3-((4-((3-(4-chlorobenzoyl)phenoxy)methyl)piperidin-1-yl)methyl)phenyl)octyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 8 h / 20 °C

With di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jm201608g