N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Base Information

Chemical Name:N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide
CAS No.:1352083-36-3
Molecular Formula:C₃₂H₃₃N₅O₃
Molecular Weight:535.646
Hs Code.:

Synonyms:N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

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Chemical Property of N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

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Technology Process of N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

There total 12 articles about N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1352083-35-2
N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

: 1352083-36-3
N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: With ammonia; dihydrogen peroxide; In tetrahydrofuran; methanol; water; at 60 ℃; for 6h;

Reference yield:

: 852620-79-2
2-azido-4-bromobenzoic acid

: 1352083-36-3
N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: HATU / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: trichlorophosphate / 2 h / 95 °C

2.2: 5 °C / Cooling with ice

3.1: 1.5 h / 175 °C

4.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere

5.1: sodium hydroxide; water / ethanol / 4 h / Reflux

5.2: pH 2

6.1: ammonium formate / palladium 10% on activated carbon / methanol / Inert atmosphere; Reflux

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

8.1: ammonia; dihydrogen peroxide / water; tetrahydrofuran; methanol / 6 h / 60 °C

With ammonia; water; dihydrogen peroxide; ammonium formate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 20776-50-5
2-amino-4-bromobenzoic acid

: 1352083-36-3
N-{1-[(4-carbamoylphenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / water / 0.5 h / 5 - 80 °C

1.2: 1 h / 0 °C

1.3: 3 h / 20 °C

2.1: HATU / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 4 h / 0 - 20 °C

3.1: trichlorophosphate / 2 h / 95 °C

3.2: 5 °C / Cooling with ice

4.1: 1.5 h / 175 °C

5.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 4 h / Reflux

6.2: pH 2

7.1: ammonium formate / palladium 10% on activated carbon / methanol / Inert atmosphere; Reflux

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

9.1: ammonia; dihydrogen peroxide / water; tetrahydrofuran; methanol / 6 h / 60 °C

With hydrogenchloride; ammonia; water; dihydrogen peroxide; ammonium formate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;