N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Base Information

Chemical Name:N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide
CAS No.:1352083-35-2
Molecular Formula:C₃₂H₃₁N₅O₂
Molecular Weight:517.63
Hs Code.:

Synonyms:N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Suppliers and Price of N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

There total 11 articles about N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1352082-73-5
3-cyclohexyl-2-phenyl-2H-indazole-6-carboxylic acid

: 1352083-22-7
1-amino-N-(4-cyanophenyl)cyclobutanecarboxamide hydrochloride

: 1352083-35-2
N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 852620-79-2
2-azido-4-bromobenzoic acid

: 1352083-35-2
N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: HATU / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: trichlorophosphate / 2 h / 95 °C

2.2: 5 °C / Cooling with ice

3.1: 1.5 h / 175 °C

4.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere

5.1: sodium hydroxide; water / ethanol / 4 h / Reflux

5.2: pH 2

6.1: ammonium formate / palladium 10% on activated carbon / methanol / Inert atmosphere; Reflux

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With water; ammonium formate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 20776-50-5
2-amino-4-bromobenzoic acid

: 1352083-35-2
N-{1-[(4-cyanophenyl)carbamoyl]cyclobutyl}-3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / water / 0.5 h / 5 - 80 °C

1.2: 1 h / 0 °C

1.3: 3 h / 20 °C

2.1: HATU / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 4 h / 0 - 20 °C

3.1: trichlorophosphate / 2 h / 95 °C

3.2: 5 °C / Cooling with ice

4.1: 1.5 h / 175 °C

5.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 4 h / Reflux

6.2: pH 2

7.1: ammonium formate / palladium 10% on activated carbon / methanol / Inert atmosphere; Reflux

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; ammonium formate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;