tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate

Base Information

Chemical Name:tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate
CAS No.:1240523-91-4
Molecular Formula:C₁₇H₁₈F₂N₂O₂
Molecular Weight:320.339
Hs Code.:

Synonyms:tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate

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Chemical Property of tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate

Chemical Property:

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Technology Process of tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate

There total 5 articles about tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 2,2-difluoro-2-(3-nitro-5-(pyridin-4-yl)phenyl)acetate

: 1240523-91-4
tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In toluene; at 20 ℃; for 2h;

Reference yield:

: 1240523-88-9
tert-butyl 2-(3-chloro-5-nitrophenyl)acetate

: 1240523-91-4
tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-Amyl alcohol / 3 h / 100 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C

2.2: 1 h / -78 °C

3.1: toluene / 1 h / 50 °C

4.1: hydrogen / palladium 10% on activated carbon / toluene / 2 h / 20 °C

With potassium phosphate; hydrogen; potassium hexamethylsilazane; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; tert-Amyl alcohol; toluene;

Reference yield:

: 219817-43-3
1-bromo-3-chloro-5-nitrobenzene

: 1240523-91-4
tert-butyl 2-(3-amino-5-(pyridin-4-yl)phenyl)-2,2-difluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; 5-cyano-2,3-di-(p-tolyl)tetrazolium chloride / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran; diethyl ether / 3 h / 20 °C

2.1: potassium phosphate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-Amyl alcohol / 3 h / 100 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C

3.2: 1 h / -78 °C

4.1: toluene / 1 h / 50 °C

5.1: hydrogen / palladium 10% on activated carbon / toluene / 2 h / 20 °C

With potassium phosphate; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; hydrogen; potassium hexamethylsilazane; 5-cyano-2,3-di-(p-tolyl)tetrazolium chloride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; tert-Amyl alcohol; diethyl ether; toluene;