Technology Process of 2,2-difluoro-2-(3-nitro-5-(pyridin-4-yl)phenyl)acetic acid
There total 3 articles about 2,2-difluoro-2-(3-nitro-5-(pyridin-4-yl)phenyl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 2-(3-nitro-5-(pyridin-4-yl)phenyl)acetate;
With
potassium hexamethylsilazane;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 0.25h;
With
2-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium phosphate; XPhos / tris-(dibenzylideneacetone)dipalladium(0) / tert-Amyl alcohol / 3 h / 100 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C
2.2: 1 h / -78 °C
With
potassium phosphate; potassium hexamethylsilazane; XPhos;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; tert-Amyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; 5-cyano-2,3-di-(p-tolyl)tetrazolium chloride / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran; diethyl ether / 3 h / 20 °C
2.1: potassium phosphate; XPhos / tris-(dibenzylideneacetone)dipalladium(0) / tert-Amyl alcohol / 3 h / 100 °C
3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C
3.2: 1 h / -78 °C
With
potassium phosphate; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; potassium hexamethylsilazane; 5-cyano-2,3-di-(p-tolyl)tetrazolium chloride; XPhos;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; tert-Amyl alcohol; diethyl ether; toluene;
