219817-43-3

Basic information

• Product Name: 1-BROMO-3-CHLORO-5-NITROBENZENE
• Synonyms: 1-BROMO-3-CHLORO-5-NITROBENZENE;1-BROMO-3-CHLORO-5-NITROBENZENE, 95+%;3-Bromo-5-chloronitrobenzene;Benzene, 1-bromo-3-chloro-5-nitro-
• CAS NO: 219817-43-3
• Molecular Formula: C6H3BrClNO2
• Molecular Weight: 236.45
• Mol File: 219817-43-3.mol

Chemical Properties

• Melting Point: 81.2 °C
• Boiling Point: 268.817°C at 760 mmHg
• Flash Point: 116.376°C
• Appearance: /
• Density: 1.827g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-BROMO-3-CHLORO-5-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-3-CHLORO-5-NITROBENZENE(219817-43-3)
• EPA Substance Registry System: 1-BROMO-3-CHLORO-5-NITROBENZENE(219817-43-3)

Safety Data

• Hazardous Substances Data: 219817-43-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-3-chloro-5-nitrobenzene serves as an intermediate in the synthesis of various pharmaceuticals, playing a crucial role in the development of new drugs and improving existing ones.
Used in Dye Industry:
In the dye industry, 1-Bromo-3-chloro-5-nitrobenzene is utilized for the production of dyes, contributing to the creation of a wide range of colorants used in different applications.
Used in Agrochemical Industry:
1-Bromo-3-chloro-5-nitrobenzene is employed in the manufacture of agrochemicals, aiding in the development of products that enhance crop protection and agricultural productivity.
Used in Organic Compounds Synthesis:
1-BROMO-3-CHLORO-5-NITROBENZENE is also used in the synthesis of other organic compounds, broadening its applications across various chemical industries.
Used as a Reagent in Organic Chemistry:
1-Bromo-3-chloro-5-nitrobenzene functions as a reagent in organic chemistry reactions, facilitating specific transformations and processes in chemical research and development.

InChI:InChI=1/C6H3BrClNO2/c7-4-1-5(8)3-6(2-4)9(10)11/h1-3H

Upstream product

• 99-29-6 1-amino-2-bromo-4-nitro-6-chlorobenzene 
• 99-54-7 3,4-dichloronitrobenzene 
• 89-61-2 2,5-dichloronitrobenzene 
• 71-43-2 benzene 
• 488850-91-5 2-(3-bromo-5-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 108-37-2 1-bromo-3-chlorobenzene 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 138-42-1 p-nitrobenzenesulfonic acid 
• 98-11-3 benzenesulfonic acid 
• 89-63-4 4-Chloro-2-nitroaniline 
• 106-46-7 para-dichlorobenzene 
• 121-87-9 2-Chloro-4-nitroaniline 
• 827-25-8 2-bromo-4-chloro-6-nitrobenzenamine 

Downstream Products

• 1240523-63-0 (S)-tert-butyl 1-(3-bromo-5-chlorophenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate 

Relevant articles and documents

meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation

Herein, we report the meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C?H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes in a one-pot fashion. This protocol allows the synthesis of meta-nitrated arenes that are tedious to prepare or require multistep synthesis using the existing methods. The reaction tolerates a wide array of ortho/para-directing groups, such as ?F, ?Cl, ?Br, ?CH3, ?Et, ?iPr ?OCH3, and ?OCF3. It also provides regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives. The application of this method is demonstrated in the late-stage modification of complex molecules and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, we have shown that the nitro product obtained by this strategy can also be directly converted to the aniline or hindered amine through Baran's amination protocol.

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Synthesis method of 3-cloro-5-bromoaniline

The invention discloses a synthesis method of 3-cloro-5-bromoaniline, and belongs to the technical field of organic synthesis. According to the method, benzenesulfonic acid is used as raw materials; firstly, concentrated nitric acid and a manganese dioxide catalyst are added for generating p-nitrobenzenesulphonic acid; then, NBS is added to generate 2-bromine p-nitrophenyl sulfonic acid; next, HCl is added for generating 2-cloro-6-bromine p-nitrophenyl sulfonic acid; next, a CH3COOH solution is added; benzenesulfonic acid in the 2-cloro-6-bromine p-nitrophenyl sulfonic acid is removed to obtain 3-cloro-5-bromonitrobenzene; finally, reducing Na2S and Zn are added for reduction, so that the 3-cloro-5-bromoaniline prepared by the method is obtained. Examples prove that the synthesis method has the advantages that the preparation is convenient and simple; the environment is protected; no pollution is caused; the equipment investment is low; any pollution does not exist; the yield reaches more than 85 percent.

NOVEL AMIDE COMPOUNDS

A compound of the formula (I):R1-A-X-NHCO-Y-R2 ???whereinR1 is heterocyclic group which may have suitable substituents, or phenyl which may have suitable substituents,R2 is condensed phenyl which may have suitable substituents, phenyl which may have suitable substituents, or thienyl which may have suitable substituents,A is a group of the formula:-(CH2)t-(O)m- or in which R3 and R4 are each hydrogen or linked together to form imino,R5 is hydrogen or lower alkyl,t is 0, 1 or 2,p, m and n are each 0 or 1,X is phenylene which may have suitable substituents, or bivalent heterocyclic group containing nitrogen which may have suitable substituents,Y is bond, lower alkylene, or lower alkenylene, and a salt thereof.