N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

Base Information

Chemical Name:N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide
CAS No.:1092392-58-9
Molecular Formula:C₂₃H₂₁N₅O₄
Molecular Weight:431.451
Hs Code.:

Synonyms:N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

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Chemical Property of N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

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Technology Process of N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

There total 9 articles about N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 38870-89-2
Methoxyacetyl chloride

: 1092394-90-5
N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-methylpyridine-2-carboxamide

: 1092392-58-9
N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

Guidance literature:: Methoxyacetyl chloride; N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-methylpyridine-2-carboxamide; In N,N-dimethyl acetamide; at 20 ℃; for 81h;

With methanol; water; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl acetamide; at 60 ℃; for 8h;

Reference yield:

: 4021-07-2
3-methyl-pyridine-2-carboxylic acid

: 1092392-58-9
N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

1.2: 13 h / 20 °C

2.1: dimethyl sulfoxide / 12 h / 20 °C

3.1: pyridine / 2 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 71 h / 20 °C

5.1: trifluoroacetic anhydride / tetrahydrofuran / 2 h / 20 °C

5.2: 19 h / 20 °C

6.1: N,N-dimethyl acetamide / 81 h / 20 °C

6.2: 8 h / 60 °C

With pyridine; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1092392-58-9
N-[3-({2-[(methoxyacetyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

3.2: 13 h / 20 °C

4.1: dimethyl sulfoxide / 12 h / 20 °C

5.1: pyridine / 2 h / 80 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 71 h / 20 °C

7.1: trifluoroacetic anhydride / tetrahydrofuran / 2 h / 20 °C

7.2: 19 h / 20 °C

8.1: N,N-dimethyl acetamide / 81 h / 20 °C

8.2: 8 h / 60 °C

With pyridine; oxalyl dichloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;