Phenol, 2-chloro-4,5-difluoro-

Base Information

• Chemical Name: Phenol, 2-chloro-4,5-difluoro-
• CAS No.: 2267-98-3
• Molecular Formula: C6H3 Cl F2 O
• Molecular Weight: 164.539
• Mol file: 2267-98-3.mol

Synonyms:6-Chloro-3,4-difluorophenol

Chemical Property of Phenol, 2-chloro-4,5-difluoro-

Chemical Property:

• Boiling Point: 93 °C (52 mmHg)
• PSA: 20.23000
• LogP: 2.32380

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4,5-difluoro-phenol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 2-chloro-4,5-difluoro-

There total 4 articles about Phenol, 2-chloro-4,5-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-difluorophenol (2713-33-9) → 6-chloro-3,4-difluorophenol (2267-98-3)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 - 25 ℃;

Reference yield:

2-chloro-4,5-difluoroaniline (2613-32-3) → 6-chloro-3,4-difluorophenol (2267-98-3)

Guidance literature:

With sulfuric acid; sodium nitrite; Erhitzen des Reaktionsgemisches mit Kupfer(II)-sulfat und wss. Schwefelsaeure auf 195grad;

DOI:10.1021/ja01510a021

Reference yield:

4-chloro-1,2-difluorobenzene (696-02-6) → 6-chloro-3,4-difluorophenol (2267-98-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; aqueous nitric acid

2: SnCl₂; aqueous HCl

3: sulfuric acid; aqueous sodium nitrite solution / Erhitzen des Reaktionsgemisches mit Kupfer(II)-sulfat und wss. Schwefelsaeure auf 195grad

With hydrogenchloride; sulfuric acid; nitric acid; tin(ll) chloride; sodium nitrite;

DOI:10.1021/ja01510a021

upstream raw materials:

2-chloro-4,5-difluoroaniline

4-chloro-1,2-difluorobenzene

2-chloro-4,5-difluoronitrobenzene

3,4-difluorophenol

Refernces