methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate

Base Information

• Chemical Name: methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate
• CAS No.: 954148-39-1
• Molecular Formula: C₂₇H₃₄O₅
• Molecular Weight: 438.564
• Mol file: 954148-39-1.mol

Synonyms:methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate

Chemical Property of methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate

There total 6 articles about methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (1R,6S)-6-(benzyloxymethyl)cyclohex-3-enecarboxylate (954148-38-0) + 1-((3-iodopropoxy)methyl)-4-methoxybenzene (198411-17-5) → methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate (954148-39-1)

Guidance literature:

methyl (1R,6S)-6-(benzyloxymethyl)cyclohex-3-enecarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

1-((3-iodopropoxy)methyl)-4-methoxybenzene; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;

DOI:10.1021/ol701772d

Reference yield:

C17H22O3 (954148-52-8) → methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate (954148-39-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate / methanol; H₂O / 0 - 20 °C

2.1: Jones' reagent / acetone / 5 °C

3.1: acetyl chloride / 0 - 20 °C

4.1: LiHMDS / tetrahydrofuran / 2 h / -78 °C

4.2: tetrahydrofuran / -78 - 20 °C

With lithium hydroxide; jones' reagent; acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; acetone;

DOI:10.1021/ol701772d

Reference yield:

((1R,6S)-6-benzyloxymethyl-cyclohex-3-enyl)-methanol (954148-37-9) → methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate (954148-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Jones' reagent / acetone / 5 °C

2.1: acetyl chloride / 0 - 20 °C

3.1: LiHMDS / tetrahydrofuran / 2 h / -78 °C

3.2: tetrahydrofuran / -78 - 20 °C

With jones' reagent; acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; acetone;

DOI:10.1021/ol701772d

upstream raw materials:

methyl (1R,6S)-6-(benzyloxymethyl)cyclohex-3-enecarboxylate

1-((3-iodopropoxy)methyl)-4-methoxybenzene

C₁₇H₂₂O₃

((1R,6S)-6-benzyloxymethyl-cyclohex-3-enyl)-methanol

Downstream raw materials:

{(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol

{(1R,6S)-6-benzyloxymethyl-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enylmethoxy}-triisopropyl-silane

3-((1R,6S)-6-benzyloxymethyl-1-(triisopropylsilanyloxy)methyl-cyclohex-3-enyl)-propan-1-ol

[(1R,6S)-1-(3-azido-propyl)-6-benzyloxymethyl-cyclohex-3-enylmethoxy]-triisopropyl-silane