{(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol

Base Information

• Chemical Name: {(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol
• CAS No.: 954148-40-4
• Molecular Formula: C₂₆H₃₄O₄
• Molecular Weight: 410.554
• Mol file: 954148-40-4.mol

Synonyms:{(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol

Chemical Property of {(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol

There total 7 articles about {(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate (954148-39-1) → {(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol (954148-40-4)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 - -20 ℃;

DOI:10.1021/ol701772d

Reference yield:

C17H22O3 (954148-52-8) → {(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol (954148-40-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hydroxide monohydrate / methanol; H₂O / 0 - 20 °C

2.1: Jones' reagent / acetone / 5 °C

3.1: acetyl chloride / 0 - 20 °C

4.1: LiHMDS / tetrahydrofuran / 2 h / -78 °C

4.2: tetrahydrofuran / -78 - 20 °C

5.1: DIBAL-H / CH₂Cl₂ / -78 - -20 °C

With lithium hydroxide; jones' reagent; diisobutylaluminium hydride; acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; acetone;

DOI:10.1021/ol701772d

Reference yield:

((1R,6S)-6-benzyloxymethyl-cyclohex-3-enyl)-methanol (954148-37-9) → {(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol (954148-40-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Jones' reagent / acetone / 5 °C

2.1: acetyl chloride / 0 - 20 °C

3.1: LiHMDS / tetrahydrofuran / 2 h / -78 °C

3.2: tetrahydrofuran / -78 - 20 °C

4.1: DIBAL-H / CH₂Cl₂ / -78 - -20 °C

With jones' reagent; diisobutylaluminium hydride; acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1021/ol701772d

upstream raw materials:

methyl (1R,6S)-6-(benzyloxymethyl)-1-(3-(4-methoxybenzyloxy)propyl)cyclohex-3-enecarboxylate

C₁₇H₂₂O₃

((1R,6S)-6-benzyloxymethyl-cyclohex-3-enyl)-methanol

methyl (1R,6S)-6-(benzyloxymethyl)cyclohex-3-enecarboxylate

Downstream raw materials:

{(1R,6S)-6-benzyloxymethyl-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enylmethoxy}-triisopropyl-silane

3-((1R,6S)-6-benzyloxymethyl-1-(triisopropylsilanyloxy)methyl-cyclohex-3-enyl)-propan-1-ol

[(1R,6S)-1-(3-azido-propyl)-6-benzyloxymethyl-cyclohex-3-enylmethoxy]-triisopropyl-silane

N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide