Ethyl 2-ethoxyprop-2-enoate

Base Information

• Chemical Name: Ethyl 2-ethoxyprop-2-enoate
• CAS No.: 22121-86-4
• Molecular Formula: C7H12 O3
• Molecular Weight: 144.17
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID60504877
• Nikkaji Number: J2.617.061C
• Wikidata: Q82359642
• Mol file: 22121-86-4.mol

Synonyms:22121-86-4;ethyl 2-ethoxy acrylate;ethyl 2-ethoxyprop-2-enoate;2-Propenoic acid,2-ethoxy-, ethyl ester;ethoxy ethyl acrylate;SCHEMBL94679;DTXSID60504877

Chemical Property of Ethyl 2-ethoxyprop-2-enoate

Chemical Property:

• Boiling Point: 178-180 °C(Press: 700 Torr)
• PSA: 35.53000
• Density: 0.9956 g/cm3(Temp: 17.200009765625 °C)
• LogP: 1.09970
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 144.078644241
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

98%Min ^*data from raw suppliers

2-Ethoxy-acrylicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=C)C(=O)OCC

Technology Process of Ethyl 2-ethoxyprop-2-enoate

There total 10 articles about Ethyl 2-ethoxyprop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

ethyl 2,2-diethoxypropionate (7476-20-2) → ethyl 2-ethoxyacrylate (22121-86-4)

Guidance literature:

With toluene-4-sulfonic acid;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (1,2-diethoxy-2-oxo-ethyl)diethylphosphonium chloride (1360565-56-5) → ethyl 2-ethoxyacrylate (22121-86-4)

Guidance literature:

(1,2-diethoxy-2-oxo-ethyl)diethylphosphonium chloride; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.833333h; Inert atmosphere;

formaldehyd; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201101072

Reference yield:

→ ethyl 2-ethoxyacrylate (22121-86-4)

Guidance literature:

With pyridine; phosphorus pentaoxide;

upstream raw materials:

ethanol

2-ethoxy-3-bromo-propionitrile

2-ethoxy-3-hydroxy-propionic acid ethyl ester

potassium acetate

Downstream raw materials:

2-ethoxy-1,1-diphenyl-allyl alcohol

ethyl 5-fluoro-1H-indole-2-carboxylate

2-carbethoxyindole

5-chloro-indole-2-carboxylic acid ethyl ester