2-(2,6-Dichloroanilino) benzaldehyde

Base Information

• Chemical Name: 2-(2,6-Dichloroanilino) benzaldehyde
• CAS No.: 22121-58-0
• Molecular Formula: C13H9 Cl2 N O
• Molecular Weight: 266.127
• Hs Code.: 2922399090
• Mol file: 22121-58-0.mol

Synonyms:Anthranilaldehyde,N-(2,6-dichlorophenyl)- (8CI); 2-(2,6-Dichloroanilino)benzaldehyde;o-(2,6-Dichloroanilino)benzaldehyde

Chemical Property of 2-(2,6-Dichloroanilino) benzaldehyde

Chemical Property:

• Melting Point: 112-114?C
• Boiling Point: 349.0±42.0 °C(Predicted)
• PKA: -4.46±0.50(Predicted)
• PSA: 29.10000
• Density: 1.392±0.06 g/cm3(Predicted)
• LogP: 4.62250
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Heated

Purity/Quality:

98%Min ^*data from raw suppliers

2-[(2,6-Dichlorophenyl)amino]benzaldehyde(Diclofenacimpurity) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Diclofenac (D436450) 2-[(2,6-Dichlorophenyl)amino]benzaldehyde (Diclofenac EP Impurity B) is an impurity of Diclofenac (D436450). Diclofenac impurity. Anti-inflammatory

Technology Process of 2-(2,6-Dichloroanilino) benzaldehyde

There total 3 articles about 2-(2,6-Dichloroanilino) benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

diclofenac sodium (15307-79-6) → 2-[(2,6-dichlorophenyl)amino]benzaldehyde (22121-58-0)

Guidance literature:

With iron(III) chloride; oxygen; In N,N-dimethyl-formamide; at 110 ℃;

DOI:10.1039/d0ob01790f

Reference yield:

methanol (67-56-1) + diclofenac sodium (15307-79-6) → 1-(2,6-dichlorophenyl)indolin-2-one (15362-40-0) + 2-[(2,6-dichlorophenyl)amino]benzaldehyde (22121-58-0) + 2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester (15307-78-5)

Guidance literature:

With water; at 19.85 ℃; for 17532h; Further Variations:; rel. humidity; complexed with β-cyclodextrin; Kinetics; Product distribution;

Reference yield:

→ 2-[(2,6-dichlorophenyl)amino]benzaldehyde (22121-58-0)

Guidance literature:

N-(2,6-Dichlorphenyl)-anthranilsaeurechlorid, Li(BuO-tert)3AlH;

upstream raw materials:

methanol

diclofenac sodium

Refernces

• 1、 Hladon, Teresa,Cwiertnia. "The effect of humidity on the stability of diclofenac sodium in inclusion complex with β-cyclodextrin in the solid state". . p. 943 - 944. Retrieved 2007/10/03.