6-chloro-2-(3,4-dichlorophenyl)-2-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine

Base Information

• Chemical Name: 6-chloro-2-(3,4-dichlorophenyl)-2-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine
• CAS No.: 102830-85-3
• Molecular Formula: C15H12 Cl3 N O
• Molecular Weight: 328.6209
• Mol file: 102830-85-3.mol

Synonyms:

Chemical Property of 6-chloro-2-(3,4-dichlorophenyl)-2-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine

Chemical Property:

• Vapor Pressure: 1.07E-07mmHg at 25°C
• Boiling Point: 445.1°Cat760mmHg
• Flash Point: 223°C
• Density: 1.375g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-2-(3,4-dichlorophenyl)-2-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine

There total 3 articles about 6-chloro-2-(3,4-dichlorophenyl)-2-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

4-(5-Chloro-2-methoxy-pyridin-3-yl)-2-(3,4-dichloro-phenyl)-butan-2-ol (102830-87-5) → 5-Chloro-3-[(E)-3-(3,4-dichloro-phenyl)-but-2-enyl]-2-methoxy-pyridine (102830-88-6) + 6-Chloro-2-(3,4-dichlorophenyl)-3,4-dihydro-2-methyl-2H-pyrano<2,3-b>pyridine (102830-85-3)

Guidance literature:

With hydrogen bromide; In acetic acid; at 100 ℃; for 0.166667h;

Reference yield:

2,5 dichloropyridine (16110-09-1) → 6-Chloro-2-(3,4-dichlorophenyl)-3,4-dihydro-2-methyl-2H-pyrano<2,3-b>pyridine (102830-85-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 75 percent / methanol / 68 h / Heating

2: 74 percent / anhydrous sodium acetate, Br₂ / acetic acid / 1.) 80 deg C, 6 h, 2.) 23 deg C, 64 h;

3: 40 percent / NaHCO₃ / palladium acetate / dimethylformamide

4: 1.99 g / tetrahydrofuran / 2 h / 23 °C

5: 5 percent / 48percent HBr / acetic acid / 0.17 h / 100 °C

With hydrogen bromide; bromine; sodium acetate; sodium hydrogencarbonate; palladium diacetate; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

3-Bromo-5-chloro-2-methoxypyridine (102830-75-1) → 6-Chloro-2-(3,4-dichlorophenyl)-3,4-dihydro-2-methyl-2H-pyrano<2,3-b>pyridine (102830-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / NaHCO₃ / palladium acetate / dimethylformamide

2: 1.99 g / tetrahydrofuran / 2 h / 23 °C

3: 5 percent / 48percent HBr / acetic acid / 0.17 h / 100 °C

With hydrogen bromide; sodium hydrogencarbonate; palladium diacetate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

4-(5-Chloro-2-methoxy-pyridin-3-yl)-2-(3,4-dichloro-phenyl)-butan-2-ol

2,5 dichloropyridine

3-Bromo-5-chloro-2-methoxypyridine

Refernces

• 1、 Bargar, T. M.,Wilson, T.,Daniel, J. K.. "3,4-Dihydro-2-phenyl-2H-pyranopyridines. Novel Aza Analogs of Flavans". . p. 1583 - 1592. Retrieved 2007/10/02.