2-chloro-β-methyl-N-phenyl-benzene ethanamine

Base Information

• Chemical Name: 2-chloro-β-methyl-N-phenyl-benzene ethanamine
• CAS No.: 1572529-59-9
• Molecular Formula: C₁₅H₁₆ClN
• Molecular Weight: 245.752
• Mol file: 1572529-59-9.mol

Synonyms:2-chloro-β-methyl-N-phenyl-benzene ethanamine

Chemical Property of 2-chloro-β-methyl-N-phenyl-benzene ethanamine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-chloro-β-methyl-N-phenyl-benzene ethanamine

There total 3 articles about 2-chloro-β-methyl-N-phenyl-benzene ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-chlorostyrene (2039-87-4,107830-52-4,26125-41-7) + aniline (62-53-3) → 1-(2-chlorophenyl)ethanone (2142-68-9) + 1-chloro-2-ethylbenzene (89-96-3) + 2-chloro-β-methyl-N-phenyl-benzene ethanamine (1572529-59-9) + N-(2-(2-chlorophenyl)propyl)aniline (103391-83-9)

Guidance literature:

With propan-1-ol; carbon monoxide; hydrogen; cetyltrimethylammonim bromide; In water; at 60 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo402632s

Reference yield: 58.0%

2-chlorostyrene (2039-87-4,107830-52-4,26125-41-7) + N-methylaniline (100-61-8) → 2-chloro-β-methyl-N-phenyl-benzene ethanamine (1572529-59-9) + N-(2-(2-chlorophenyl)propyl)aniline (103391-83-9) + N-(1,5-bis(2-chlorophenyl)pentan-3-yl)aniline

Guidance literature:

With bis((3,5-diisopropylphenyl)(6-((3,5-diisopropylphenyl)amino)pyridin-2-yl)amino)bis(dimethylamino)titanium; In toluene; at 140 ℃; for 24h; Reagent/catalyst; Catalytic behavior; Schlenk technique; Glovebox;

DOI:10.1002/ejoc.202001337

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 2-chloro-β-methyl-N-phenyl-benzene ethanamine (1572529-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 20 °C / Inert atmosphere; Schlenk technique

1.2: 2 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: bis((3,5-diisopropylphenyl)(6-((3,5-diisopropylphenyl)amino)pyridin-2-yl)amino)bis(dimethylamino)titanium / toluene / 24 h / 140 °C / Schlenk technique; Glovebox

With n-butyllithium; bis((3,5-diisopropylphenyl)(6-((3,5-diisopropylphenyl)amino)pyridin-2-yl)amino)bis(dimethylamino)titanium; In tetrahydrofuran; hexane; toluene; 1.1: |Wittig Rearrangement / 1.2: |Wittig Rearrangement;

DOI:10.1002/ejoc.202001337

upstream raw materials:

2-chlorostyrene

aniline

N-methylaniline

2-chloro-benzaldehyde