Technology Process of 2,3,4,5-tetra-O-benzyl-6-O-trityl-D-altrose propane-1,3-diyldithioacetal
There total 1 articles about 2,3,4,5-tetra-O-benzyl-6-O-trityl-D-altrose propane-1,3-diyldithioacetal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-O-trityl-D-altrose propane-1,3-diyl dithioacetal;
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 0.5h;
benzyl bromide;
With
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
DOI:10.1021/jo400130p
- Guidance literature:
-
With
methanol; sulfuric acid;
In
dichloromethane;
at 20 ℃;
DOI:10.1021/jo400130p
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sulfuric acid; methanol / dichloromethane / 20 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C
4: potassium carbonate; methanol / 3 h / 20 °C
5: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.33 h / -70 °C
6: sodium hydrogencarbonate; hydroxylamine hydrochloride; methanol / 20 °C
7: sodium cyanoborohydride; hydrogenchloride; methanol / 20 °C / pH 3 - 4
8: hydrogenchloride / tetrahydrofuran / 2 h / 20 °C
With
hydrogenchloride; methanol; N-Bromosuccinimide; oxalyl dichloride; sulfuric acid; hydroxylamine hydrochloride; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; triethylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo400130p
