1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea

Base Information

Chemical Name:1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea
CAS No.:1418149-79-7
Molecular Formula:C₂₇H₂₄ClN₉O₂S
Molecular Weight:574.066
Hs Code.:

Synonyms:1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea

There total 11 articles about 1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.2%

: 1418149-58-2
7-(4-methylpiperazin-1-yl)-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazolin-6-amine

: 3320-83-0
o-chlorophenyl isocyanate

: 1418149-79-7
1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1007/s00044-012-0408-0

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1418149-79-7
1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / 3 h / 160 °C

2.1: potassium carbonate / isopropyl alcohol / 7 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Reflux

3.2: 5 h / Reflux

4.1: acetic acid; iron / water / 5 h / 10 - 20 °C

5.1: N,N-dimethyl-formamide / 12 h / 20 °C

With phosphorus pentachloride; iron; potassium carbonate; acetic acid; In water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1007/s00044-012-0408-0

Reference yield:

: 59-67-6
nicotinic acid

: 1418149-79-7
1-(2-chlorophenyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 4 h / 20 °C / Reflux

2.1: hydrazine hydrate / ethanol / Reflux

3.1: potassium hydroxide / ethanol / 5 h / Reflux

4.1: potassium carbonate / isopropyl alcohol / 7 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Reflux

5.2: 5 h / Reflux

6.1: acetic acid; iron / water / 5 h / 10 - 20 °C

7.1: N,N-dimethyl-formamide / 12 h / 20 °C

With potassium hydroxide; sulfuric acid; iron; potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1007/s00044-012-0408-0