[(2-Methylphenyl)amino]acetic acid

Base Information

• Chemical Name: [(2-Methylphenyl)amino]acetic acid
• CAS No.: 21911-61-5
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.192
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID50944506
• Nikkaji Number: J2.265.367I
• Wikidata: Q82921730
• Mol file: 21911-61-5.mol

Synonyms:21911-61-5;[(2-methylphenyl)amino]acetic acid;N-(2-methylphenyl)glycine;2-(o-tolylamino)acetic acid;2-(2-methylanilino)acetic acid;Glycine, N-(methylphenyl)-;2-[(2-methylphenyl)amino]acetic Acid;2-toluidinoacetic acid;112708-10-8;MFCD00503961;o-Toluylglycin;o-Tolylamino-acetic acid;SCHEMBL196636;DTXSID50944506;2-(2-TOLUIDINO)ACETIC ACID;AKOS000101582;LS-01427;BB 0240670;CS-0308961;FT-0678939;EN300-144391;F79814;AE-562/33905058;F2118-0018

Chemical Property of [(2-Methylphenyl)amino]acetic acid

Chemical Property:

• Vapor Pressure: 5.1E-06mmHg at 25°C
• Refractive Index: 1.604
• Boiling Point: 366.6°C at 760 mmHg
• Flash Point: 175.5°C
• PSA: 49.33000
• Density: 1.211g/cm³
• LogP: 1.56450
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

98%Min ^*data from raw suppliers

N-(2-Methylphenyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1NCC(=O)O

Technology Process of [(2-Methylphenyl)amino]acetic acid

There total 10 articles about [(2-Methylphenyl)amino]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl bromoacetate (105-36-2) + o-toluidine (95-53-4) → N-(2-methylphenyl)glycine (21911-61-5)

Guidance literature:

ethyl bromoacetate; o-toluidine; With silica gel; at 20 ℃; for 0.133333h; microwave irradiation;

With sodium hydroxide; In ethanol; for 0.166667h; Heating;

DOI:10.3987/COM-05-10574

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + methylene chloride (74-87-3) + N-o-tolyl-N-(N-o-tolyl-glycyl)-glycine → N-(2-methylphenyl)glycine (21911-61-5) + o-toluidine (95-53-4)

Guidance literature:

at 150 - 160 ℃;

Reference yield:

chloroacetic acid (79-11-8) + o-toluidine (95-53-4) → N-(2-methylphenyl)glycine (21911-61-5)

Guidance literature:

With water;

upstream raw materials:

1-methyl-2-nitrobenzene

chloroacetic acid

o-toluidine

sodium monochloroacetic acid

Downstream raw materials:

N-(2-methylphenyl)glycine ethyl ester

N-nitroso-N-o-tolyl-glycine

1,4-bis(2-methylphenyl)piperazine-2,5-dione

o-toluidine