4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate

Base Information

Chemical Name:4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate
CAS No.:92817-79-3
Molecular Formula:C₂₉H₄₂O₅
Molecular Weight:470.649
Hs Code.:

Synonyms:4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate

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Chemical Property of 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate

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Technology Process of 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate

There total 6 articles about 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78-84-2
isobutyraldehyde

: 92817-70-4
4'-methyl-2,6-di-tert-butylphenyl 2-(4methoxyphenoxy)propanoate

: 92817-80-6
4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate

: 92817-79-3
4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Yield given. Yields of byproduct given;
DOI:10.1021/ja00338a027

Reference yield:

: 13794-15-5,4276-73-7,4276-75-9
2-(4-methoxyphenoxy)propanoic acid

: 92817-79-3
4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / SOCl₂ / dimethylformamide / 1 h / Heating

2: 45 percent / 1.5 M n-BuLi / tetrahydrofuran; hexane / -78 °C

3: LDA / tetrahydrofuran / 0.5 h / -78 °C

With n-butyllithium; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ja00338a027

Reference yield:

: 128-37-0
2,6-di-tert-butyl-4-methyl-phenol

: 92817-79-3
4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / 1.5 M n-BuLi / tetrahydrofuran; hexane / -78 °C

2: LDA / tetrahydrofuran / 0.5 h / -78 °C

With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/ja00338a027