1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Base Information

Chemical Name:1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole
CAS No.:228259-14-1
Molecular Formula:C₁₆H₁₃F₃N₂O₃
Molecular Weight:338.286
Hs Code.:

Synonyms:1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

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Technology Process of 1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

There total 6 articles about 1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 543-27-1
isobutyl chloroformate

: 228259-13-0
1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

: 228259-14-1
1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Guidance literature:: With 4-methyl-morpholine; sodium borohydrid; In tetrahydrofuran; hexane; water;

Reference yield:

: C₂₁H₁₉F₃N₂O₆

: 228259-14-1
1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-14-1
1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: AcOH / 4 h / 100 °C

2: N-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

3: 1.5 g / NaBH₄ / tetrahydrofuran; H₂O

With 4-methyl-morpholine; sodium tetrahydroborate; acetic acid; In tetrahydrofuran; water;
DOI:10.1021/jm030212h