1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Base Information

• Chemical Name: 1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole
• CAS No.: 228259-13-0
• Molecular Formula: C₁₆H₁₁F₃N₂O₄
• Molecular Weight: 352.27

Synonyms:1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Chemical Property of 1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

Chemical Property:

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Technology Process of 1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

There total 3 articles about 1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methyl-1-(2-aminomethyl-4-methoxyphenyl)-1H-pyrazole-5-(N-(2'-sulfamido-[1,1']-biphen-4-yl))carboxyamide, trifluoroacetic acid salt + 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione (326-90-9) → 1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole (228259-13-0)

Guidance literature:

In chloroform; water; acetic acid;

Reference yield:

2-Amino-5-methoxybenzoic acid (6705-03-9) → 1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole (228259-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HCl; NaNO₂ / H₂O / 0.5 h / 0 °C

1.2: SnCl₂*2H₂O; HCl / H₂O / 3 h / 0 - 20 °C

2.1: AcOH / 4 h / 100 °C

With hydrogenchloride; acetic acid; sodium nitrite; In water;

DOI:10.1021/jm030212h

Reference yield:

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione (326-90-9) + 2-carboxy-4-methoxyphenylhydrazine (228259-02-7) → 1-(2-carboxy-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole (228259-13-0)

Guidance literature:

With acetic acid; at 100 ℃; for 4h;

DOI:10.1021/jm030212h

upstream raw materials:

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

2-carboxy-4-methoxyphenylhydrazine

2-Amino-5-methoxybenzoic acid

Downstream raw materials:

1-(2-hydroxymethyl-4-methoxyphenyl)-3-trifluoromethyl-5-(furan-2-yl)-1H-pyrazole

2-(2-aminomethyl-4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

1-(2-azidomethyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2-fluoro-4-(2-N-tert-butylaminosulfonyl)-[1,1]-biphen-4-yl))carboxamide

2-(2-azidomethyl-4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

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