2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile

Base Information

• Chemical Name: 2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile
• CAS No.: 1193512-04-7
• Molecular Formula: C₁₅H₁₁F₃N₂O
• Molecular Weight: 292.26
• Mol file: 1193512-04-7.mol

Synonyms:2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile

Chemical Property of 2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile

There total 1 articles about 2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide + 2,6-difluoro-3-methoxybenzaldehyde (149949-30-4) + 4-fluoroaniline (371-40-4) → 2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile (1193512-04-7)

Guidance literature:

With 2,4,6-trifluorobenzaldehyde; In tetrahydrofuran; at 20 ℃;

Reference yield:

2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile (1193512-04-7) + N-(bromomethylene)-N-methylmethanaminium bromide (24774-61-6) → 4-bromo-5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-1H-imidazole (1193352-37-2)

Guidance literature:

2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile; N-(bromomethylene)-N-methylmethanaminium bromide; In dichloromethane; at 80 ℃; for 0.0166667h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

2,6-difluoro-α-[(4-fluorophenyl)amino]-3-methoxybenzeneacetonitrile (1193512-04-7) → 5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole (1193353-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 0.02 h / 80 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 60 °C

3: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Reflux

With N-Bromosuccinimide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

2,6-difluoro-3-methoxybenzaldehyde

4-fluoroaniline

Downstream raw materials:

4-bromo-5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-1H-imidazole

2,4-dibromo-5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-1H-imidazole

5-(2,6-difluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-2,4-dimethyl-1H-imidazole