6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Base Information

Chemical Name:6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide
CAS No.:1092508-35-4
Molecular Formula:C₂₆H₂₉FN₄O₆
Molecular Weight:512.538
Hs Code.:

Synonyms:6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide

There total 9 articles about 6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092508-23-0
2-(4-{2-[(6-fluoro-2-{[(3-methoxybenzyl)amino]carbonyl}-4-oxo-3,4-dihydroquinazolin-5-yl)oxy]ethyl}piperidin-1-yl)-2-oxoethyl acetate

: 1092508-35-4
6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Guidance literature:: 2-(4-{2-[(6-fluoro-2-{[(3-methoxybenzyl)amino]carbonyl}-4-oxo-3,4-dihydroquinazolin-5-yl)oxy]ethyl}piperidin-1-yl)-2-oxoethyl acetate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 1h;

With potassium hydrogensulfate; water; In tetrahydrofuran; pH=~ 7;

Reference yield:

: 869299-06-9
ethyl 5,6-difluoroanthranilate hydrochloride

: 1092508-35-4
6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; acetic acid / water / 3 h / 80 °C

2.1: triethylamine / tetrahydrofuran / 48 h / 20 °C

3.1: sodium hydride / N,N-dimethyl acetamide / 0.08 h / 20 °C

3.2: 1 h / 60 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: dmap; triethylamine / dichloromethane / 0.5 h / 20 °C

6.1: lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

6.2: pH ~ 7

With hydrogenchloride; dmap; lithium hydroxide; water; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 869294-99-5
ethyl 5,6-difluoro-4-oxo-3,4-dihydroquinazoline-2-carboxylate

: 1092508-35-4
6-fluoro-5-[2-(1-glycoloylpiperidin-4-yl)ethoxy]-N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 48 h / 20 °C

2.1: sodium hydride / N,N-dimethyl acetamide / 0.08 h / 20 °C

2.2: 1 h / 60 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: dmap; triethylamine / dichloromethane / 0.5 h / 20 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

5.2: pH ~ 7

With dmap; lithium hydroxide; water; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;