tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate

Base Information

• Chemical Name: tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate
• CAS No.: 864515-95-7
• Molecular Formula: C₂₀H₂₅NO₄S₂
• Molecular Weight: 407.555
• Mol file: 864515-95-7.mol

Synonyms:tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate

Chemical Property of tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate

There total 1 articles about tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl benzoylacetate (54441-66-6) + (E)-1-(2-thioxothiazolidin-3-yl)but-2-en-1-one → tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate (864515-95-7) + tert-butyl (3S)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate

Guidance literature:

With [Ni((S)-Tol-BINAP)](BF₄)2; In ethyl acetate; at 0 ℃; for 12h; Title compound not separated from byproducts;

DOI:10.1021/ja053820q

Reference yield:

tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate (864515-95-7) → tert-butyl (R)-4-methyl-6-oxo-2-phenyl-5,6-dihydro-4H-pyran-3-carboxylate

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃;

DOI:10.1021/ja053820q

Reference yield:

tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate (864515-95-7) + methanol (67-56-1) → (S)-3-methyl-5-oxo-5-phenyl-pentanoic acid methyl ester

Guidance literature:

tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate; methanol; With potassium carbonate; In ethyl acetate;

With toluene-4-sulfonic acid; In benzene; for 2h; Heating;

DOI:10.1021/ja053820q

upstream raw materials:

tert-butyl benzoylacetate