4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester

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Chemical Name:4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester
CAS No.:1048035-15-9
Molecular Formula:C₂₈H₃₂ClFN₄O₄S
Molecular Weight:575.104
Hs Code.:

Synonyms:4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester

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Chemical Property of 4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester

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Technology Process of 4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester

There total 11 articles about 4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1048034-94-1
(2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-phenyl)-methanol

: 403-43-0
4-fluorobenzoyl chloride

: 1048035-15-9
4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

Reference yield:

: 117738-76-8
3-Cyano-4-chloro-benzoic acid

: 1048035-15-9
4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h

2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

2.2: 18 h / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

4.1: hydrogenchloride; water / acetone / 18 - 20 h / 55 °C

5.1: acetic acid / dichloromethane / 0.17 h

5.2: 60 h

6.1: diisobutylaluminium hydride / dichloromethane; toluene / 4.5 h / 0 - 20 °C

7.1: sodium tetrahydroborate / ethanol / 6 h

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; water; diisobutylaluminium hydride; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1048034-83-8
2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

: 1048035-15-9
4-fluoro-benzoic acid 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

2.1: hydrogenchloride; water / acetone / 18 - 20 h / 55 °C

3.1: acetic acid / dichloromethane / 0.17 h

3.2: 60 h

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 4.5 h / 0 - 20 °C

5.1: sodium tetrahydroborate / ethanol / 6 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With hydrogenchloride; sodium tetrahydroborate; water; diisobutylaluminium hydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;