1,3,5-Triphenylpyrazole

Base Information

• Chemical Name: 1,3,5-Triphenylpyrazole
• CAS No.: 2183-27-9
• Molecular Formula: C21H16 N2
• Molecular Weight: 296.371
• Hs Code.: 2933199090
• Mol file: 2183-27-9.mol

Synonyms:Pyrazole,1,3,5-triphenyl- (6CI,7CI,8CI); 1,3,5-Triphenyl-1H-pyrazole;1,3,5-Triphenylpyrazole

Chemical Property of 1,3,5-Triphenylpyrazole

Chemical Property:

• PSA: 17.82000
• LogP: 5.20630

Purity/Quality:

99%min ^*data from raw suppliers

1,3,5-TRIPHENYL-1H-PYRAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,5-Triphenylpyrazole

There total 142 articles about 1,3,5-Triphenylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,3,5-triphenyl-4,5-dihydro-1H-pyrazole (742-01-8) → 1,3,5-triphenyl-1H-pyrazole (2183-27-9)

Guidance literature:

With bismuth (III) nitrate pentahydrate; acetic acid; for 0.00972222h; microwave irradiation;

DOI:10.1080/00397910500214136

Reference yield: 98.0%

1,3-diphenylpropanedione (120-46-7,61346-73-4) + phenylhydrazine (100-63-0) → 1,3,5-triphenyl-1H-pyrazole (2183-27-9)

Guidance literature:

With aluminum oxide; at 20 ℃; for 72h;

DOI:10.1055/s-1986-31655

Reference yield: 95.0%

phenylhydrazine (100-63-0) + 1,3-diphenyl-propen-3-one (614-47-1) → 1,3,5-triphenyl-1H-pyrazole (2183-27-9)

Guidance literature:

palladium on activated charcoal; K-10 montmorillonite; In dichloromethane; at 160 ℃; for 0.5h; microwave irradiation;

DOI:10.1055/s-2007-982545

upstream raw materials:

chalcone epoxide

acetic acid

phenylhydrazine

1,3,5-triphenyl-4,5-dihydro-1H-pyrazole

Downstream raw materials:

phenyl(1,3,5-triphenyl-1H-pyrazol-4-yl)methanone

1-methyl-2,3,5-triphenyl-pyrazolium; iodide

1,3,5-triphenyl-4,5-dihydro-1H-pyrazole

4-bromo-1,3,5-triphenyl-1H-pyrazole

Refernces

• 1、 Azarifar, Davood,Maleki, Behrooz. "Microwave-assisted aromatization of 1,3,5-trisubstituted 2-pyrazolines by silica-supported N-bromosuccinimide as a useful reagent under solvent free 'dry' condition". . p. 865 - 870. Retrieved 2005.
• 2、 Ghorbani-Vaghei, Ramin,Azarifar, Davood,Maleki, Behrooz. "Mild oxidation of 1,3,5-trisubstituted pyrazolines with N-bromo-sulphonamides". . p. 1373 - 1376. Retrieved 2004.
• 3、 Nakhmanovich A. S.,Glotova, T. E.. "NEW METHOD FOR THE SYNTHESIS OF 1,3,5-TRIPHENYLPYRAZOLE". . p. 955. Retrieved 1985.
• 4、 Azarifar, Davood,Zolfigol, Mohammad Ali,Maleki, Behrooz. "Silica-supported 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a useful reagent for microwave-assisted aromatization of 1,3,5-trisubstituted pyrazolines under solvent-free conditions". . p. 1744 - 1746. Retrieved 2004.
• 5、 Kolla, Sai Teja,Somanaboina, Ramya,Bhimapaka, China Raju. "TBHP/Cu(OAc)2 mediated oxidation of pyrazolines: A convenient method for the preparation of pyrazoles". supporting information. p. 1425 - 1432. Retrieved 2021/02/27.
• 6、 Xiong, Wenfang,Wu, Bowen,Zhu, Baiyao,Tan, Xiaobin,Wang, Lu,Wu, Wanqing,Qi, Chaorong,Jiang, Huanfeng. "One-Pot Palladium-Catalyzed Carbonylative Sonogashira Coupling using Carbon Dioxide as Carbonyl Source". . p. 2843 - 2851. Retrieved 2021/05/10.