1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine

Base Information

• Chemical Name: 1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine
• CAS No.: 374629-49-9
• Molecular Formula: C₁₆H₁₅N₅O
• Molecular Weight: 293.328
• Mol file: 374629-49-9.mol

Synonyms:1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine

Chemical Property of 1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine

There total 3 articles about 1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

guanidine hydrochloride (50-01-1) + 3-bromo-2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepine (66752-03-2) → 4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one (16439-95-5) + 1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine (374629-49-9)

Guidance literature:

With potassium carbonate; In acetone; for 1h; Reflux;

DOI:10.1002/jhet.2573

Reference yield: 82.0%

guanidine hydrochloride (50-01-1) + 3-bromo-2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepine (66752-03-2) → 1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine (374629-49-9)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In 1,4-dioxane;

DOI:10.1081/SCC-100105132

Reference yield:

4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one (16439-95-5) → 1-(2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-3-yl)guanidine (374629-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / CHCl₃

2: 82 percent / potassium carbonate; tetrabutylammonium bromide / dioxane

With tetrabutylammomium bromide; bromine; potassium carbonate; In 1,4-dioxane; chloroform;

DOI:10.1081/SCC-100105132

upstream raw materials:

guanidine hydrochloride

3-bromo-2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepine

4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one